03-P075 The repulsive guidance molecule (RGM) family in chicken
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چکیده
منابع مشابه
03-P075 The repulsive guidance molecule (RGM) family in chicken
anism would thus be a new way to form a tube. As the generation of the lumen and of the tube itself requires the apparition of an apical domain, we decided to investigate how part of the lateral domain becomes apical. Our first results, using transgenes driven by brachyury regulating sequences, show that several proteins classically involved in antero-posterior and planar polarities could be in...
متن کاملRepulsive Guidance Molecule (RGM) Family Proteins Exhibit Differential Binding Kinetics for Bone Morphogenetic Proteins (BMPs)
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor beta superfamily that exert their effects via type I and type II serine threonine kinase receptors and the SMAD intracellular signaling pathway to regulate diverse biologic processes. Recently, we discovered that the repulsive guidance molecule (RGM) family, including RGMA, RGMB, and RGMC/hemojuvelin (HJV), functio...
متن کاملMolecular biology, genetics and biochemistry of the repulsive guidance molecule family.
RGMs (repulsive guidance molecules) comprise a recently discovered family of GPI (glycosylphosphatidylinositol)-linked cell-membrane-associated proteins found in most vertebrate species. The three proteins, RGMa, RGMb and RGMc, products of distinct single-copy genes that arose early in vertebrate evolution, are approximately 40-50% identical to each other in primary amino acid sequence, and sha...
متن کاملRepulsive guidance molecule (RGM) gene function is required for neural tube closure but not retinal topography in the mouse visual system.
The establishment of topographic projections in the developing visual system depends on the spatially and temporally controlled expression of axon guidance molecules. In the developing chick tectum, the graded expression of the repulsive guidance molecule (RGM) has been proposed to be involved in controlling the topography of the retinal ganglion cell (RGC) axon termination zones along the ante...
متن کاملChromophore-assisted laser inactivation of a repulsive axonal guidance molecule
BACKGROUND The axons of retinal ganglion neurons from a precise topographic map in the optic tectum in the midbrain, and the guidance of retinal axons by directional cues in the tectum is crucial in this process. Several in vitro systems have been developed in order to identify the molecular basis of these directional cues. Temporal, but not nasal, retinal axons avoid posterior tectal membranes...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2009
ISSN: 0925-4773
DOI: 10.1016/j.mod.2009.06.128